Collagen induction therapy (CIT) is an aesthetic medical procedure that involves repeatedly puncturing the skin with tiny, sterile needles (microneedling the skin) in order to induce endogenous production of cutaneous collagen. CIT is often referred to as “microneedling” or “skin needling” in media and literature, however it is important to distinguish CIT from other contexts in which microneedling devices are used on the skin, e.g. transdermal drug delivery, vaccination, etc. The procedure usually involves a specialized device which can take the form of a manual rolling device or an automated stamping device. The rolling devices, also known as “microrollers” have been used since the late 1990s and marketed under various names, such as the “Dermaroller”® invented by the founder of the eponymous company Horst Liebl and patented in 2000,. The automated microneedle stamping devices, or “microneedling pens”, are typically powered by a motor and can be adjusted for frequency (stamps/second) and depth of the microneedles. These “pens” are also marketed under various names, such as SkinPen, DermaPen and Micropen.