Major trauma is injury that can potentially lead to serious outcomes. For research purposes the definition is often based on an injury severity score (ISS) of greater than 15. There are many causes of injury that can affect a person in different ways, both anatomically and physiologically. Depending on the severity of injury, quick management and transport to an appropriate facility may be necessary to prevent loss of life or limb. Various classification scales exist for use with trauma to determine the severity of injuries, which is used to determine the resources used and for statistical collection. The initial assessment is critical in determining the extent of injuries and what will be needed to manage an injury, and treating immediate life threats. The assessment involves a physical evaluation and can also include the use of imaging tools to accurately determine a type of injury and to formulate a course of treatment. In 2002, unintentional and intentional injuries were the fifth and seventh leading causes of deaths worldwide, accounting for 6.23% and 2.84% of all deaths.