The Testosterone-Diabetes Connection

African man is sitting at the sofa and taking blood from his finger due to diabetes. The daily life of a man of African-American ethnicity person with a chronic illness who is using glucose tester.
Medically Reviewed
July 16, 2024

Do you feel like you’ve lost your edge? Low energy, declining muscle mass, and a dip in libido could be signs of low testosterone. But for men with diabetes, these symptoms can be even more concerning. Research shows a strong link between low testosterone and type 2 diabetes, creating a double whammy for your health.  

As a hormone replacement expert, I see this connection all too often. Let’s delve into the reasons behind low T and diabetes and explore how managing both conditions can get you back on track. 

Testosterone 101: The Male Powerhouse Hormone 

Testosterone, the primary male sex hormone, plays a vital role in countless bodily functions. It’s responsible for: 

  • Muscle building and strength: Testosterone promotes muscle growth and repair, giving men their characteristic strength and physique. 
  • Bone health: It helps maintain strong bones and prevents osteoporosis. 
  • Fat metabolism: Testosterone influences how the body stores and utilizes fat, promoting a healthy body composition. 
  • Sex drive and libido: Testosterone fuels a man’s sex drive and plays a crucial role in erectile function. 
  • Energy levels and mood: Testosterone impacts energy production and can influence mood and motivation. 
  • Cognitive function: Some studies suggest testosterone may play a role in cognitive function and memory. 

Low Testosterone and Increased Risk of Diabetes: 

Now, let’s explore the concerning link between testosterone and diabetes. Here’s the key takeaway: there’s a two-way street at play. 

  • Insulin resistance: Testosterone helps cells respond to insulin, the hormone responsible for regulating blood sugar levels. When testosterone levels drop, cells become less sensitive to insulin, leading to a condition called insulin resistance. This, in turn, can lead to type 2 diabetes. 
  • Visceral fat: Low testosterone levels are associated with increased visceral fat, the unhealthy fat stored around the abdomen. This type of fat is particularly linked to insulin resistance and diabetes risk. 
  • Metabolic syndrome: Low testosterone is often a component of metabolic syndrome, a cluster of conditions that includes high blood pressure, unhealthy cholesterol levels, and insulin resistance, all of which increase the risk of diabetes. 

Diabetes and Worsened Testosterone Deficiency: 

  • Inflammation: Chronic hyperglycemia (high blood sugar) associated with diabetes can contribute to inflammation throughout the body. This inflammation can damage the testes, further reducing testosterone production. 
  • Obesity: Obesity, a common risk factor for both diabetes and low testosterone, can create a vicious cycle. Excess fat tissue increases the production of an enzyme that binds to testosterone, making it less available to cells. 

Addressing Low T: Can Testosterone Replacement Therapy Help Manage Diabetes? 

The good news is that research suggests testosterone replacement therapy (TRT) can be a valuable tool in managing diabetes, particularly for men with both low testosterone and poorly controlled blood sugar. Here’s how TRT might benefit diabetic men: 

  • Improved insulin sensitivity: Studies have shown that TRT can improve insulin sensitivity, making cells more responsive to insulin and potentially leading to better blood sugar control. 
  • Reduced visceral fat: TRT may help reduce visceral fat accumulation, a significant contributor to insulin resistance. 
  • Overall metabolic health: Studies suggest TRT can improve overall metabolic health by impacting cholesterol levels and body composition. 

Important Considerations for TRT in Diabetic Men 

While TRT offers promising benefits for diabetic men with low testosterone, it’s crucial to approach it with caution. Here are some key points to consider: 

  • Individualized approach: Not every diabetic man with low testosterone will be a candidate for TRT. A thorough evaluation by a qualified healthcare professional is essential. 
  • Blood sugar monitoring: Close monitoring of blood sugar levels becomes even more critical during TRT. 
  • Potential risks: TRT can have side effects, such as increased red blood cell count or sleep apnea. Discussing these risks with your doctor is essential. 

Beyond Diabetes: The Broader Benefits of Rebalancing Testosterone 

While the connection between testosterone and diabetes is significant, the benefits of addressing low testosterone extend far beyond blood sugar control. Men with low T often experience a constellation of symptoms, including: 

  • Decreased libido and erectile dysfunction 
  • Fatigue and low energy 
  • Muscle loss and weight gain 
  • Depression and mood swings 
  • Cognitive decline 

Fortunately, TRT can significantly improve these quality-of-life factors. Studies show men undergoing TRT experience: 

  • Increased energy levels and improved mood 

If you’re one of the millions of men living with diabetes, understanding the connection between low testosterone and blood sugar control is crucial. By working with your doctor to address hormonal imbalances, you can harness the power of testosterone replacement therapy to improve your diabetes management and reclaim your overall well-being. Remember, you’re not alone in this journey – a hormone replacement expert can help you navigate this path to a healthier you. 

Disclaimer: This blog post is intended for informational purposes only and should not be construed as medical advice. Please consult with your healthcare provider to discuss your specific needs and treatment options. 

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A Medical Director, and one of the first physicians to join the Nava Health & Vitality Center, Dr. Douglas Lord has made significant contributions to our Center and its founding principles. Dr. Lord has helped develop and implement the Nava Method™—Nava’s proprietary approach to total body wellness. He has also been instrumental in liaising with other expert practitioners to successfully implement Nava’s range of therapies, treatments, and products.